A community-based multicenter trial of pharmacokinetically

A community-based multicenter trial of pharmacokinetically guided 5-fluorouracil dosing for personalized colorectal cancer therapy. Patel JN, O’Neil BH, Deal AM, et al. Oncologist. 2014 [...]

Open-label randomized study of individualized pharmacokinetically (PK)-guided dosing versus body surface area (BSA) dosing of paclitaxel (PTX) in advanced Non-Small Cell Lung Cancer (NSCLC)

Open-label randomized study of individualized pharmacokinetically (PK)-guided dosing versus body surface area (BSA) dosing of paclitaxel (PTX) in advanced Non-Small Cell Lung Cancer (NSCLC) Ann [...]

Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer

Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer Bruno R, Hille D, Riva A, et al. J Clin Oncol. 1998;16:187-96 This study demonstrated that it [...]

Pharmacokinetics, dynamics and toxicity of docetaxel: Why the Japanese dose differs from the Western dose

Pharmacokinetics, dynamics and toxicity of docetaxel: Why the Japanese dose differs from the Western dose Kenmotsu H, Tanigawara Y. Cancer Sci. 2015;106:497-504 This review details studies in the [...]

Therapeutic Drug Monitoring for the Individualization of Docetaxel Dosing: A Randomized Pharmacokinetic Study

Therapeutic Drug Monitoring for the Individualization of Docetaxel Dosing: A Randomized Pharmacokinetic Study Engels FK, Loos WJ, van der Bol JM, et al. Clin Cancer Res. 2011;17:353-62 High and [...]

Personalized Medicine Initiatives

Paclitaxel Pharmacokinetics And Response To Chemotherapy

Paclitaxel Pharmacokinetics And Response To Chemotherapy In Patients With Advanced Cancer Treated With A Weekly Regimen This studied followed others in observing that paclitaxel pharmacokinetics [...]

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