Therapeutic Drug Monitoring for the Individualization of Docetaxel Dosing: A Randomized Pharmacokinetic Study
Engels FK, Loos WJ, van der Bol JM, et al. Clin Cancer Res. 2011;17:353-62
High and unpredictable interpatient variation can lead to unpredictable toxicity and lack of efficacy with docetaxel chemotherapy. This study demonstrated that therapeutic drug monitoring with a limited sampling strategy could be used to pharmacokinetically adjust doses. The variability of both docetaxel blood levels and the percentage decrease in neutrophil count were both reduced.