A community-based multicenter trial of pharmacokinetically

A community-based multicenter trial of pharmacokinetically guided 5-fluorouracil dosing for personalized colorectal cancer therapy. Patel JN, O’Neil BH, Deal AM, et al. Oncologist. 2014 [...]

Personalized Dosing via Pharmacokinetic Monitoring of 5-FU

Personalized Dosing via Pharmacokinetic Monitoring of 5-Fluorouracil Might Reduce Toxicity in Early- or Late-Stage Colorectal Cancer Patients Treated With Infusional 5-Fluorouracil-Based [...]

Modeling the 5-fluorouracil area under the curve versus dose relationship

Modeling the 5-fluorouracil area under the curve versus dose relationship to develop a pharmacokinetic dosing algorithm for colorectal cancer patients receiving FOLFOX6. Kaldate RR, Haregewoin A, [...]

Individual Fluorouracil Dose Adjustment

Individual Fluorouracil Dose Adjustment Based on Pharmacokinetic Follow-Up Compared With Conventional Dosage: Results of a Multicenter Randomized Trial of Patients With Metastatic Colorectal [...]

Prospective, multi-center study of 5-FU

Prospective, multi-center study of 5-fluorouracil (5-FU) therapeutic drug management (TDM) in metastatic colorectal cancer (mCRC) patients treated in routine clinical practice.Wilhelm M, Mueller [...]

Therapeutic drug monitoring of 5-fluorouracil

Therapeutic drug monitoring of 5-fluorouracil.   Lee JJ, Beumer JH, Chu E. Cancer Chemother Pharmacol. 2016 78(3):447-464. Review. This very recent and through review concluded: “Dose adjustment [...]