The Wrong Dose Harms Patients

As Doctors, we seek the best care for our patients, but current practice dictates dosing regimens that are either ineffective or toxic to our patients. It’s time to change our approach to treating patients.

MyCare Oncology addresses these current practices in dosing through a new, efficacious form of delivery that provides physicians and caregivers with a full, accurate measure of the patient’s individual dosage requirements.

Clinical Studies

IMATINIB CLINICAL STUDY

Increase the Rates of Molecular Responses in Patients with Chronic Myeloid Leukemia

In this study sixty-five percent of CML patients had imatinib levels below the established therapeutic threshold (Cmin or Ctrough). Measuring patient’s Cmin and adjusting dosage resulted in significantly higher imatinib plasma levels and major molecular responses (63%) compared to standard management for patients below the Cmin target (37%). The magnitude of major molecular response with dose adjustment is comparable to that reported for second generation tyrosine kinase inhibitors.

5-FLUOROURACIL CLINICAL STUDY

Therapeutic Drug Monitoring in Oncology: IATDMCT Recommendations for 5-Fluorouracil Therapy

Patient care evolves around evidence based guidelines. An expert working committee of clinician-scientists tasked by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology reviewed the available peer-reviewed literature.

TDM of 5-FU was strongly recommended for dose titration. The required evidence is: established therapeutic ranges, demonstrated improved action and/or lower toxicity in controlled TDM clinical trials. The clinical outcome is: therapeutic blood levels give the highest probability of response, “subtherapeutic” levels have the risk of lower response rates, “supratherapeutic” levels increase the risk of toxicity.

PACLITAXEL CLINICAL STUDY

TDM of Paclitaxel Reduces Severe Toxicity and Maintains Efficacy

Neutropenia and neuropathy can be serious side-effects associated with paclitaxel chemotherapy. While hematological toxicities can be addressed, there is no good solution for chemotherapy induced peripheral neuropathy, which is frequent, may be debilitating and can persist or appear after treatment. One of the largest randomized TDM studies ever demonstrated the potential of paclitaxel dose optimization to:

  • Reduce neuropathy
  • Reduce neutropenia
  • Without impacting survival
DOCETAXEL CLINICAL STUDY

Docetaxel Pharmacokinetics Predicts Neutropenia and Outcomes

The docetaxel pharmacokinetic parameter Area Under the Curve (AUC) was associated with neutropenia and time to progression in non-small cell lung cancer patients.

Clinical Support

FINDINGS

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